Published

Brain cellular senescence in mouse models of Alzheimer's disease.

Geroscience


Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in tauopathy

Nature Communications


Primary neuron and astrocyte cultures from postnatal Callithrix jacchus: A non-human primate in vitro model for research in neuroscience, nervous system aging, and neurological diseases of aging 

Geroscience


Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment 


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American Journal of Physiology Heart & Circulation Physiology



PUBLICATIONS

1.       Dorigatti AO, Riordan R, Yu Z, Ross G, Wang R, Reynolds-Lallement N, Magnusson K, Galvan V, Perez VI. "Brain cellular senescence in mouse models of Alzheimer's disease." (2022) Geroscience. doi: 10.1007/s11357-022-00531-5. 

2.      Strong R, Miller RA, Cheng CJ, Nelson JF, Gelfond J, Allani SK, Diaz V, Dorigatti AO, Dorigatti J, Fernandez E, Galecki A, Ginsburg B, Hamilton KL, Javors MA, Kornfeld K, Kaeberlein M, Kumar S, Lombard DB, Lopez-Cruzan M, Miller BF, Rabinovitch P, Reifsnyder P, Rosenthal NA, Bogue MA, Salmon AB, Suh Y, Verdin E, Weissbach H, Newman J, Maccchiarini F, Harrison DE. "Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice." (2022).  Aging Cell. doi: 10.1111/acel.13724.

3.      Hussong S.A., Banh, A.Q., Van Skike, C.E., Dorigatti, A.O., Hernandez, S.F., Hart, M.J., Gaczynska, M., Osmulski, P.A., McAllen, S.A., Dineley, K.T., Ungvari, Z., Pérez, V.I., Kayed, R., and Galvan, V. “Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in tauopathy.” (2023). Nat Commun. doi: 10.1038/s41467-023-37840-y.

4.     Dorigatti A.O.*, Hussong S.A.*, Hernandez S.F., Sills A.M., Salmon A., Galvan V. "Primary neuron and astrocyte cultures from postnatal Callithrix jacchus: A non-human primate in vitro model for research in neuroscience, nervous system aging, and neurological diseases of aging." (2021). GeroScience. Geroscience. doi: 10.1007/s11357-020-00284-z.*denotes equal contribution.

5.     Van Skike, C. E.*, Jahrling, J.B.*, Olson, A.B., Sayre, N.L., Hussong, S.A., Ungvari,Z.I., Lechleiter, J.D., Galvan, V. (2017). "Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment." Am J Physiol Heart Circ Physiol. *denotes equal contribution **Received the American Physiological Society APSselect Award Feb. 2018.

Technical Acknowledgement. Schmidt, K., & Loeb Belinsky, K. (2013). Voices in the dark: Predation risk by owls influences dusk singing in a diurnal passerine. Behavioral Ecology and Sociobiology, 67(11), 1837-1843.

 

PUBLICATIONS IN PREPARATION FOR SUBMISSION

1.     Dorigatti, A.O., Riordan R., Yu, Z., Ross G., Wang R., Galvan V., Perez V. “Characterizing Cellular Senescence in Mouse Models of Alzheimer’s Disease” In preparation for submission

2.     Dorigatti, A.O., C.E. Van Skike, V. Galvan. “Pathogenic tau in cerebrovascular dysfunction in Alzheimer’s disease.” Invited review. Front Aging Neurosci. In preparation for submission.

3.     Dorigatti, A.O., Cirrito, J., V. Galvan. “mTOR attenuation promotes amyloid beta clearance through LRP1 and PICALM.” J Cereb Blood F Met. In preparation for submission.

4.     Dorigatti, A.O., Hernandez, S.F., Hussong, S.A., Kayed, R., Galvan, V. “Tau-induced astrocyte senescence as a driver of neuronal dysfunction in Alzheimer’s disease” In preparation for submission.